Bioorganic & Medicinal Chemistry Letters 2001-07-09

A mechanism-based affinity-labeling agent for possible use in isolating N-acetylglucosaminidase.

M Ichikawa, Y Ichikawa

Index: Bioorg. Med. Chem. Lett. 11 , 1769-1773, (2001)

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Abstract

We have prepared several mechanism-based affinity-labeling agents for possible use in isolating N-acetylglucosaminidase, in which an N-acetylglucosamine is linked to an o-monofluoro- or difluoro-methyl phenoxy glycoside with or without a cleavable disulfide group in the tether to biotin.