Journal of Pharmaceutical and Biomedical Analysis 2008-12-15

Determination of amprolium in feed by a liquid chromatography-mass spectrometry method.

S Squadrone, C Mauro, G L Ferro, G Amato, M C Abete

Index: J. Pharm. Biomed. Anal. 48(5) , 1457-61, (2008)

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Abstract

As a consequence of the finding of veterinarian drugs in food European Community banned several compounds like coccidiostats as amprolium (APL). This antibiotic has been used as a preventive and clinical anticoccidial drug in chicken. The 2005/187/CE, 2005/925/EC Recommendations ban the use of amprolium as additive in chicken feed. For this reason a rapid and sensitive liquid chromatography-mass spectrometry (LC-MS) method was developed to detect amprolium in chicken feed following the European community proposed technique (1999/27/EC) for sample preparation. Cause the validation is required for the analytical methods used in feed official control, this method was validated according to 2004/882/EC Regulation.