Synthesis, in vitro antiplatelet activity and molecular modelling studies of 10-substituted 2-(1-piperazinyl) pyrimido [1, 2-a] benzimidazol-4 (10H)-ones

…, MG Signorello, G Leoncini, E Cichero, P Fossa…

Index: Di Braccio, Mario; Grossi, Giancarlo; Signorello, Maria Grazia; Leoncini, Giuliana; Cichero, Elena; Fossa, Paola; Alfei, Silvana; Damonte, Gianluca European Journal of Medicinal Chemistry, 2013 , vol. 62, p. 564 - 578

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Citation Number: 9

Abstract

The multistep preparation of the new 10-substituted 2-(1-piperazinyl) pyrimido [1, 2-a] benzimidazol-4 (10H)-ones 6a–o, and of the two isomers 10-ethyl-2-(diethylamino) pyrimido [1, 2-a] benzimidazol-4 (10H)-one 6p and 10-ethyl-4-(diethylamino) pyrimido [1, 2-a] benzimidazol-2 (10H)-one 13, as well as the in vitro evaluation of their inhibitory activity on human platelet aggregation induced in platelet-rich plasma by ADP, collagen or the Ca2+ ...