(E)-Phenyl-and-heteroaryl-substituted O-benzoyl-(or acyl) oximes as lipoprotein-associated phospholipase A 2 inhibitors

TS Jeong, MJ Kim, H Yu, KS Kim, JK Choi…

Index: Jeong, Tae-Sook; Kim, Mi Jeong; Yu, Hana; Kim, Kyung Soon; Choi, Joong-Kwon; Kim, Sung-Soo; Lee, Woo Song Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 5 p. 1525 - 1527

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Citation Number: 26

Abstract

A series of (E)-phenyl-and-heteroaryl-substituted O-benzoyl-(or acyl) oximes 3a–n were synthesized for evaluating their human lipoprotein-associated phospholiphase A2 (Lp- PLA2) inhibitory activities. The less lipophilic derivatives 3a–c showed the most potent in vitro inhibitory activity on human Lp-PLA2.