e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Liebigs Annalen der Chemie

Organische Schwefelverbindungen, L. 2H??Thiopyrane und Dihydro??2H??thiopyrane, Synthone für Thiophene

K Praefcke, C Weichsel

Index: Praefcke, Klaus; Weichsel, Christian Liebigs Annalen der Chemie, 1980 , # 10 p. 1604 - 1619

Full Text: HTML

Citation Number: 5

Abstract

Abstract 2H-Thiopyran-Derivate liefern durch Pyrolyse bei 240-260 C Thiophene. Einflüsse von Substitutionen in 3-bis 6-Stellung der 2H-Thiopyrane auf diese neuen thermischen Umlagerungs-und Fragmentierungsreaktionen sowie mechanistische Vorstellungen darüber werden ausführlich diskutiert. Unsere Ergebnisse beschreiben ein neues, dreistufiges Synthesekonzept für Thiophene aus Carbonylverbindungen über ...

3,6-Dihydro-2,2-bis(4-methoxyphenyl)-4,5-dimethyl-2H-thiopyran Structure

3,6-Dihydro-2,2...

~32%

3,4-Dimethylthiophene Structure

3,4-Dimethylthi...

Benzene,1,1'-methylenebis[4-methoxy- Structure

Benzene,1,1'-me...

2-Bis(4-methoxyphenyl)methyl-3,4-dimethylthiophen Structure

2-Bis(4-methoxy...

Spiro[xanthen-9',2-(3,6-dihydro-4,5-dimethyl-2H-thiopyran-S-oxid)] Structure

Spiro[xanthen-9...

~0%

3,4-Dimethylthiophene Structure

3,4-Dimethylthi...

Xanthene Structure

9-(9H-xanthen-9-yl)-9H-xanthene Structure

9-(9H-xanthen-9...

Detail

Spiro[xanthen-9',2-(3,6-dihydro-4,5-dimethyl-2H-thiopyran)] Structure

Spiro[xanthen-9...

~18%

Xanthene Structure

xanthene-9-thione Structure

xanthene-9-thione

9-(9H-xanthen-9-yl)-9H-xanthene Structure

9-(9H-xanthen-9...

Detail

Spiro[xanthen-9',2-(3,6-dihydro-4,5-dimethyl-2H-thiopyran-S-oxid)] Structure

Spiro[xanthen-9...

~0%

3,4-Dimethylthiophene Structure

3,4-Dimethylthi...

Xanthene Structure

9-(9H-xanthen-9-yl)-9H-xanthene Structure

9-(9H-xanthen-9...

Detail

3,4-Dimethyl-2-(9'-xanthenyl)thiophen Structure

3,4-Dimethyl-2-...

~%

Xanthene Structure

9-(9H-xanthen-9-yl)-9H-xanthene Structure

9-(9H-xanthen-9...

Spiro[xanthen-9',2-(3,6-dihydro-4,5-dimethyl-2H-thiopyran)] Structure

Spiro[xanthen-9...

~18%

3,4-Dimethylthiophene Structure

3,4-Dimethylthi...

Xanthene Structure

tetramethylethylene Structure

tetramethylethylene

Detail

3,6-Dihydro-2,2,4,5-tetraphenyl-2H-thiopyran Structure

3,6-Dihydro-2,2...

~21%

Thiophene,3,4-diphenyl- Structure

Thiophene,3,4-d...

Diphenylmethane Structure

Diphenylmethane

N/A Structure

1',4',5',6',7',8'-hexahydrospiro[fluorene-9,3'-isothiochromene] Structure

1',4',5',6',7',...

~10%

4,5,6,7-tetrahydro-1-benzothiophene Structure

4,5,6,7-tetrahy...

9H FLUORENE Structure

N/A Structure

Detail

3-(9'-Fluorenyl)-1,3,4,5,6,7-hexahydrobenzo[c]thiophen Structure

3-(9'-Fluorenyl...

~%

4,5,6,7-tetrahydro-1-benzothiophene Structure

4,5,6,7-tetrahy...

9H FLUORENE Structure

N/A Structure

Spiro[xanthen-9',2-(3,6-dihydro-4,5-dimethyl-2H-thiopyran)] Structure

Spiro[xanthen-9...

~26%

Xanthene Structure

xanthene-9-thione Structure

xanthene-9-thione

9-(9H-xanthen-9-yl)-9H-xanthene Structure

9-(9H-xanthen-9...

Detail

Spiro[xanthen-9',2-(3,6-dihydro-4,5-dimethyl-2H-thiopyran)] Structure

Spiro[xanthen-9...

~26%

3,4-Dimethylthiophene Structure

3,4-Dimethylthi...

Xanthene Structure

tetramethylethylene Structure

tetramethylethylene

Detail

Spiro[thioxanthen-9',2-(3,6-dihydro-4,5-dimethyl-2H-thiopyran)] Structure

Spiro[thioxanth...

~6%

3,4-Dimethylthiophene Structure

3,4-Dimethylthi...

thioxanthene Structure

tetramethylethylene Structure

tetramethylethylene

Detail

Spiro[xanthen-9',2-(3,6-dihydro-4,5-dimethyl-2H-thiopyran-S-oxid)] Structure

Spiro[xanthen-9...

~0%

3,4-Dimethylthiophene Structure

3,4-Dimethylthi...

Xanthene Structure

9-(9H-xanthen-9-yl)-9H-xanthene Structure

9-(9H-xanthen-9...

Detail

Spiro[xanthen-9',2-(3,6-dihydro-4,5-dimethyl-2H-thiopyran)] Structure

Spiro[xanthen-9...

~51%

Xanthene Structure

xanthene-9-thione Structure

xanthene-9-thione

9-(9H-xanthen-9-yl)-9H-xanthene Structure

9-(9H-xanthen-9...

Detail

Spiro[xanthen-9',2-(3,6-dihydro-4,5-dimethyl-2H-thiopyran)] Structure

Spiro[xanthen-9...

~50%

3,4-Dimethylthiophene Structure

3,4-Dimethylthi...

Xanthene Structure

tetramethylethylene Structure

tetramethylethylene

Detail

Spiro[fluoren-9',2-(6,6-dideuterio-3,6-dihydro-4,5-dimethyl-2H-thiopyran)] Structure

Spiro[fluoren-9...

~39%

3,4-Dimethylthiophene Structure

3,4-Dimethylthi...

9H FLUORENE Structure

2-(9H-fluoren-9-yl)-3,4-dimethylthiophene Structure

2-(9H-fluoren-9...

3',6'-Dihydro-4',5'-dimethylspiro(fluoren-9,2'-[6,6-D2]-[2H]thiopyran)-1'-oxid Structure

3',6'-Dihydro-4...

~25%

3,4-Dimethylthiophene Structure

3,4-Dimethylthi...

9H FLUORENE Structure

2-(9H-fluoren-9-yl)-3,4-dimethylthiophene Structure

2-(9H-fluoren-9...

Spiro[fluoren-9',2-(6-deuterio-4,5-dimethyl-2H-thiopyran)] Structure

Spiro[fluoren-9...

~37%

3,4-Dimethylthiophene Structure

3,4-Dimethylthi...

9H FLUORENE Structure

2-(9H-fluoren-9-yl)-3,4-dimethylthiophene Structure

2-(9H-fluoren-9...

4',5'-dimethylspiro[fluorene-9,2'-thiopyran] Structure

4',5'-dimethyls...

~25%

3,4-Dimethylthiophene Structure

3,4-Dimethylthi...

9H FLUORENE Structure

2-(9H-fluoren-9-yl)-3,4-dimethylthiophene Structure

2-(9H-fluoren-9...

3',6'-Dihydro-4',5'-dimetylspiro(fluoren-9,2'-[2H]thiopyran)-1'-oxid Structure

3',6'-Dihydro-4...

~38%

3,4-Dimethylthiophene Structure

3,4-Dimethylthi...

9H FLUORENE Structure

2-(9H-fluoren-9-yl)-3,4-dimethylthiophene Structure

2-(9H-fluoren-9...

Spiro[thioxanthen-9',2-(3,6-dihydro-4,5-dimethyl-2H-thiopyran)] Structure

Spiro[thioxanth...

~9%

3,4-Dimethylthiophene Structure

3,4-Dimethylthi...

thioxanthene Structure

9-(9H-thioxanthen-9-yl)-9H-thioxanthene Structure

9-(9H-thioxanth...

Detail

Spiro[thioxanthen-9',2-(3,6-dihydro-4,5-dimethyl-2H-thiopyran)] Structure

Spiro[thioxanth...

~10%

3,4-Dimethylthiophene Structure

3,4-Dimethylthi...

thioxanthene Structure

tetramethylethylene Structure

tetramethylethylene

Detail

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