Catalytic, Asymmetric, and Stereodivergent Synthesis of Non-Symmetric β, β-Diaryl-α-Amino Acids

C Molinaro, JP Scott, M Shevlin, C Wise…

Index: Hyett, David J.; Didone, Mara; Milcent, Thierry J.A.; Broxterman, Quirinus B.; Kaptein, Bernard Tetrahedron Letters, 2006 , vol. 47, # 44 p. 7771 - 7774

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Citation Number: 22

Abstract

... J. Am. ... Table b ... Screening of phosphine ligand, Pd precatalyst, base and solvent in tandem with DoE optimization identified the use of Pd(OAc) 2 (0.5 mol %), 1,4-bis(diphenylphosphino) butane (dppb) (1.1 mol %) and K 3 PO 4 (100 mol %) in 2-MeTHF (10 vol) and water (5 vol ...