Neurobiology of Aging 1991-01-01

Methanesulfonyl fluoride enhances one-trial reward learning in mid-aged rats.

D H Malin, P J Toups, L D Osgood, D E Fowler, C L Hunter, K R Arcangeli, D E Moss

Index: Neurobiol. Aging 12(2) , 181-3, (1991)

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Abstract

In previous studies, 18-month-old rats have shown no significant retention 24 hours after the single acquisition trial in a one-trial discriminative reward learning task. In the present study, ten 18-month-old rats pretreated with 0.5 mg/kg MSF IP showed significantly better retention in terms of speed and errors than eleven 18-month-old rats pretreated with injection vehicle alone. However, twelve two-three-month-old rats pretreated with the same dose of MSF failed to show better retention than eleven two-three-month-old rats pretreated with vehicle alone.