Tetrahedron: Asymmetry

Chemoenzymatic synthesis of both enantiomers of 3-hydroxy-and 3-amino-3-phenylpropanoic acid

A Varga, V Zaharia, M Nógrádi, L Poppe

Index: Varga, Annamaria; Zaharia, Valentin; Nogradi, Mihaly; Poppe, Laszlo Tetrahedron Asymmetry, 2013 , vol. 24, # 21-22 p. 1389 - 1394

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Citation Number: 4

Abstract

Abstract Ethyl (S)-3-hydroxy-3-phenylpropionate (S)-2 was obtained by the asymmetric reduction of ethyl 3-phenyl-3-oxopropionate 1 with the yeast Saccharomyces cerevisiae (ATCC 9080). The kinetic resolution of racemic ethyl 2-acetoxy-3-phenyl-propionate rac-3 with the same microorganism, gave after hydrolysis ethyl (R)-and (S)-3-hydroxy-3- phenylpropionates (R)-2 and (S)-2 which were converted by a straightforward series of ...