Bioorganicheskaia khimiia 2008-01-01

[Polymethylene nucleic acid derivatives with omega-functional groups: vi. [8-(2-oxocyclohexyl)-9-oxooctyl]pyrimidines as potential inhibitors of pyrimidine phosphorylases].

V V Komissarov, N G Panova, A M Kritsyn

Index: Bioorg. Khim. 34(1) , 75-82, (2008)

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Abstract

New polymethylene derivatives of nucleic bases with beta-diketo function in omega-position were prepared by alkylation of uracil, thymine, and cytosine. Their physicochemical properties and effect on the E. coli uridine phosphorylase were studied.