Bulletin of Experimental Biology and Medicine 2008-01-01

Blood plasma proteins modulate the broncholytic effects of a muscarinic receptor antagonist.

G I Nezhinskaya, A L Vladykin, N S Sapronov

Index: Bull. Exp. Biol. Med. 145(1) , 55-7, (2008)

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Abstract

Blood plasma proteins modulated the effects of muscarinic receptor antagonist methacin. Administration of methacin in combination with albumin or C-reactive protein (but not with IgG) abolished the broncholytic effect of methacin. It was probably associated with allosteric antagonism to M2, cholinergic receptors on non-nervous cells, which increased antibody production and mediator response. The concentration of serotonin in mesenteric lymph nodes was high during shock.