FEBS Journal 2010-05-01

Effects of a novel arginine methyltransferase inhibitor on T-helper cell cytokine production.

Kevin Bonham, Saskia Hemmers, Yeon-Hee Lim, Dawn M Hill, M G Finn, Kerri A Mowen

Index: FEBS J. 277(9) , 2096-108, (2010)

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Abstract

The protein arginine methyltransferase (PRMT) family of enzymes catalyzes the transfer of methyl groups from S-adenosylmethionine to the guanidino nitrogen atom of peptidylarginine to form monomethylarginine or dimethylarginine. We created several less polar analogs of the specific PRMT inhibitor arginine methylation inhibitor-1, and one such compound was found to have improved PRMT inhibitory activity over the parent molecule. The newly identified PRMT inhibitor modulated T-helper-cell function and thus may serve as a lead for further inhibitors useful for the treatment of immune-mediated disease.