Chemical & Pharmaceutical Bulletin 2011-01-01

A new way for synthesis of phenoxazine and diphenoxazine derivatives via electrochemical method.

Saied Saeed Hosseiny Davarani, Majid Kalate Bojdi, Ali Mehdinia

Index: Chem. Pharm. Bull. 59(10) , 1209-13, (2011)

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Abstract

Electrochemical oxidation of hydroquinone (1a) and 2,3-dimethylhydroquinone (1b) have been studied in the presence of 2-aminophenol (3a) and 2-amino-4-chlorophenol (3b), as nucleophiles in phosphate buffer solution (pH 7.2) using cyclic voltammetry and controlled potential coulometry. We proposed different mechanisms for the electrode process. The products were derived with good yield and purity using controlled-potential electrochemical oxidation of 1a, b in the presence of 3a and 3b at the graphite electrode in an undivided cell.