Organic Letters 2006-04-27

New air-stable catalysts for general and efficient suzuki-miyaura cross-coupling reactions of heteroaryl chlorides.

Anil S Guram, Anthony O King, John G Allen, Xianghong Wang, Laurie B Schenkel, Johann Chan, Emilio E Bunel, Margaret M Faul, Robert D Larsen, Michael J Martinelli, Paul J Reider

Index: Org. Lett. 8 , 1787, (2006)

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Abstract

[reaction: see text] New air-stable PdCl(2){P(t)Bu(2)(p-R-Ph)}(2) (R = H, NMe(2), CF(3),) complexes represent simple, general, and efficient catalysts for the Suzuki-Miyaura cross-coupling reactions of aryl halides including five-membered heteroaryl halides and heteroatom-substituted six-membered heteroaryl chlorides with a diverse range of arylboronic acids. High product yields (89-99% isolated yields) and turn-over-numbers (10,000 TON) are observed.