Nucleosides, Nucleotides & Nucleic Acids 2001-01-01

Dealkylation of phosphonate esters with chlorotrimethylsilane.

A J Gutierrez, E J Prisbe, J C Rohloff

Index: Nucleosides Nucleotides Nucleic Acids 20(4-7) , 1299-302, (2001)

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Abstract

Chlorotrimethylsilane completely dealkylates phosphonate esters at elevated temperature in a sealed reaction vessel. These conditions are tolerated by a variety of functional groups and lead to high conversions of dimethyl, diethyl and diisopropyl phosphonates to their corresponding phosphonic acids.