Biochemical and Biophysical Research Communications 2012-06-22

AIRE-induced apoptosis is associated with nuclear translocation of stress sensor protein GAPDH

Ingrid Liiv, Uku Haljasorg, Kai Kisand, Julia Maslovskaja, Martti Laan, Pärt Peterson, Ingrid Liiv, Uku Haljasorg, Kai Kisand, Julia Maslovskaja, Martti Laan, Pärt Peterson

Index: Biochem. Biophys. Res. Commun. 423(1) , 32-7, (2012)

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Abstract

Highlights ► AIRE induces apoptosis in epithelial cells. ► CARD domain of AIRE is sufficient for apoptosis induction. ► AIRE induced apoptosis involves GAPDH translocation to the nuclei. ► Deprenyl inhibits AIRE induced apoptosis.