Abstract The synthesis of new bischromone derivatives (4a–c and 5a–c) as potential anticancer drugs is described. The difference in the reactivity between 4-oxo-4H-chromene- 3-carboxylic acid 2 (or its methyl ester 3) and 4-oxo-4H-chromene-3-carbonyl chloride 1 with three different polyamines: 3, 3′-diamino-N-methyldipropylamine (a), 1, 4-bis (3- aminopropyl) piperazine (b), 4, 9-dioxa-1, 12-dodecanediamine (c) resulted in the ...