Synthesis and biological evaluation of new bischromone derivatives with antiproliferative activity

A Szulawska??Mroczek, M Szumilak…

Index: Szulawska-Mroczek, Agata; Szumilak, Marta; Szczesio, Malgorzata; Olczak, Andrzej; Nazarski, Ryszard B.; Lewgowd, Wieslawa; Czyz, Malgorzata; Stanczak, Andrzej Archiv der Pharmazie, 2013 , vol. 346, # 1 p. 34 - 43

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Citation Number: 7

Abstract

Abstract The synthesis of new bischromone derivatives (4a–c and 5a–c) as potential anticancer drugs is described. The difference in the reactivity between 4-oxo-4H-chromene- 3-carboxylic acid 2 (or its methyl ester 3) and 4-oxo-4H-chromene-3-carbonyl chloride 1 with three different polyamines: 3, 3′-diamino-N-methyldipropylamine (a), 1, 4-bis (3- aminopropyl) piperazine (b), 4, 9-dioxa-1, 12-dodecanediamine (c) resulted in the ...