Bioorganic & Medicinal Chemistry Letters 1999-02-22

Inhibition of 4-hydroxyphenylpyruvate dioxygenase by sethoxydim, a potent inhibitor of acetyl-coenzyme A carboxylase.

S Lin, D Yang

Index: Bioorg. Med. Chem. Lett. 9(4) , 551-4, (1999)

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Abstract

Sethoxydim, a commercially available cyclohexanedione class herbicide by targeting the enzymatic activity of acetyl-coenzyme A carboxylase, has been found to moderately inhibit the activity of 4-hydroxyphenylpyruvate dioxygenase, a key enzyme in the biosynthesis of plastoquinones and tocopherols in plants.