Toxicology in Vitro 2011-01-01

Genotoxic effects of polychlorinated biphenyls (PCB 153, 138, 101, 118) in a fish cell line (RTG-2)

Laura Marabini, Rossella Calò, Serena Fucile, Laura Marabini, Rossella Calò, Serena Fucile

Index: Toxicol. In Vitro 25(5) , 1045-52, (2011)

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Abstract

Highlights ► We investigate the genotoxic effects of some PCBs (153, 138 and 118 non-dioxin-like compounds and 101 non-dioxin-like compound in fish cells RTG-2. ► The loss of DNA integrity is considered as an initial step for the identification of genotoxic effects. ► The alkaline comet assay and the micronucleus test show clear genotoxic damage after 2 and 24 h to maximum soluble, non-cytotoxic doses. ► Oxidative stress situations seem the most likely explanation for the genotoxic damage.