Chemical Communications 2008-10-21

Diaryl ether synthesis in supercritical carbon dioxide in batch and continuous flow modes.

Jin-Kyun Lee, Matthew J Fuchter, Rachel M Williamson, Gary A Leeke, Edward J Bush, Ian F McConvey, Simon Saubern, John H Ryan, Andrew B Holmes

Index: Chem. Commun. (Camb.) (39) , 4780-2, (2008)

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Abstract

A high yielding, batch mode synthesis of diaryl ethers and sulfides by an S(N)Ar fluoride-mediated process in scCO(2) has been developed; the use of a polymer-supported imidazolium fluoride reagent in batch mode led to the development of a fixed-bed continuous flow process, with high conversions.