Ecotoxicology and Environmental Safety 1982-02-01

Metabolism and distribution of 2,4-dimethylphenol in rat.

J S Kaka, S M Somani, D J Schaeffer

Index: Ecotoxicol. Environ. Saf. 6(1) , 35-40, (1982)

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Abstract

The concentration of 2,4-DMP was determined for several tissues of the rat by gas chromatographic methods after 6 hr constant intravenous infusion and after intravenous bolus injection. 2,4-DMP was distributed rapidly in the brain and liver. It has higher tissue-plasma concentration ratios for the brain, liver, and fat. Accumulation of 2,4-DMP in these tissues appears to be negligible. 2,4-DMP is rapidly metabolized to its conjugates (94.3%) within 30 min; gluronide constitutes 53% and other conjugates 41%.