Mild and Efficient Copper??Catalyzed Cyanation of Aryl Iodides and Bromides

…, A Ouali, JF Spindler, M Taillefer

Index: Cristau, Henri-Jean; Ouali, Armelle; Spindler, Jean-Francis; Taillefer, Marc Chemistry - A European Journal, 2005 , vol. 11, # 8 p. 2483 - 2492

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Citation Number: 151

Abstract

Abstract An efficient copper-catalyzed cyanation of aryl iodides and bromides is reported. Our system combines catalytic amounts of both copper salts and chelating ligands. The latter, which have potential nitrogen-and/or oxygen-binding sites, have never previously been used in this type of reaction. A protocol has been developed that enables the cyanation of aryl bromides through the copper-catalyzed in situ production of the ...