Chemical Communications 2012-06-07

In vitro chemoenzymatic and in vivo biocatalytic syntheses of new beauvericin analogues.

Diana Matthes, Lennart Richter, Jane Müller, Alexander Denisiuk, Sven C Feifel, Yuquan Xu, Patricia Espinosa-Artiles, Roderich D Süssmuth, István Molnár

Index: Chem. Commun. (Camb.) 48(45) , 5674-6, (2012)

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Abstract

New beauvericins have been synthesized using the nonribosomal peptide synthetase BbBEAS from the entomopathogenic fungus Beauveria bassiana. Chemical diversity was generated by in vitro chemoenzymatic and in vivo whole cell biocatalytic syntheses using either a B. bassiana mutant or an E. coli strain expressing the bbBeas gene.