Toxicology in Vitro 2011-12-01

Trichloroethanol up-regulates matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in HaCaT cells

Haijun Yang, Yufei Dai, Haiyan Dong, Dan Zang, Qing Liu, Huawei Duan, Yong Niu, Ping Bin, Yuxin Zheng

Index: Toxicol. In Vitro 25(8) , 1638-43, (2011)

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Abstract

Highlights ► We assess sensitizing potential of trichloroethanol or trichloroacetic acid in vitro. ► We use HaCaT cell line as mode cell and matrix metalloproteinases as responders. ► TCOH could induce MMP-9 increase in a dose–effect mode in HaCaT cell. ► TCA could not induce such a response in HaCaT cell. ► TCOH might play important roles in trichloroethylene-induced hypersensitivity reaction.