Chemical Communications 2011-10-28

Heavily fluorinated carbohydrates as enzyme substrates: oxidation of tetrafluorinated galactose by galactose oxidase.

Avgousta Ioannou, Elena Cini, Roxana S Timofte, Sabine L Flitsch, Nicholas J Turner, Bruno Linclau

Index: Chem. Commun. (Camb.) 47(40) , 11228-30, (2011)

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Abstract

Galactose oxidase (GOase) was shown to oxidise several C2/C3 fluorinated galactose analogues. Interestingly, the enzyme was able to distinguish between the 2,3-tetrafluorinated galactose and its epimeric glucose analogue, and this represents the first reported biotransformation of a heavily fluorinated sugar.This journal is © The Royal Society of Chemistry 2011