Journal of the American Chemical Society 2011-06-22

Enantioselective bromoaminocyclization using amino-thiocarbamate catalysts.

Ling Zhou, Jie Chen, Chong Kiat Tan, Ying-Yeung Yeung

Index: J. Am. Chem. Soc. 133 , 9164-9167, (2011)

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Abstract

A facile and efficient enantioselective bromoaminocyclization of unsaturated sulfonamides has been developed using an amino-thiocarbamate catalyst. A range of enantioenriched pyrrolidines were prepared with up to 99% yield and 99% ee. The corresponding lactams could be obtained through oxidation of the pyrrolidines.