Bioorganic & Medicinal Chemistry Letters 2000-06-19

Synthesis and resolution of racemic eliprodil and evaluation of the enantiomers of eliprodil as NMDA receptor antagonists.

J Pabel, G Höfner, K T Wanner

Index: Bioorg. Med. Chem. Lett. 10(12) , 1377-80, (2000)

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Abstract

A short synthesis of the NMDA receptor antagonist (rac)-Eliprodil (9) and its resolution into the enantiomers by chiral HPLC is described. The enantiomers (R)-9 and (S)-9 were found to exhibit markedly different affinities for NR2B subunit containing NMDA receptors.