Chemical & Pharmaceutical Bulletin 2002-09-01

Stereoselective synthesis of tetrasubstituted (Z)-alkenes from aryl alkyl ketones utilizing the Horner-Wadsworth-Emmons reaction.

Shigeki Sano, Tomoka Takehisa, Shiho Ogawa, Kenji Yokoyama, Yoshimitsu Nagao

Index: Chem. Pharm. Bull. 50(9) , 1300-2, (2002)

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Abstract

Tetrasubstituted (Z)-alkenes were readily prepared through the Horner-Wadsworth-Emmons reactions of methyl 2-[bis(2,2,2-trifluoroethyl)phosphono]propionate with aryl alkyl ketones by employing Sn(OSO(2)CF(3))(2) and N-ethylpiperidine.