International Journal of Peptide and Protein Reseach 1982-11-01

Acid-labile resin linkage agents for use in solid phase peptide synthesis.

R C Sheppard, B J Williams

Index: Int. J. Pept. Protein Res. 20(5) , 451-4, (1982)

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Abstract

Details are given of the preparation of two acid-labile peptide-resin linkage agents for use in solid phase peptide synthesis, viz. 4-hydroxymethylphenoxy-acetic acid and 3-methoxy-4-hydroxymethylphenoxyacetic acid. The latter is suitable for the preparation of peptide fragments bearing t-butyl-based side chain protecting groups.