Bioorganic & Medicinal Chemistry 2002-09-01

Synthesis of new 2,5-disubstituted-1,3,4-thiadiazoles and preliminary evaluation of anticonvulsant and antimicrobial activities.

Hatice N Dogan, Arzu Duran, Sevim Rollas, Göksel Sener, Meral K Uysal, Dumrul Gülen

Index: Bioorg. Med. Chem. 10(9) , 2893-8, (2002)

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Abstract

Two new series of 2,5-disubstituted-1,3,4-thiadiazoles were synthesized for their possible anticonvulsant, antibacterial and antifungal activities. The degree of protection afforded by these compounds at a dose of 100mg/kg i.p. against pentylenetetrazole-induced convulsions in mice ranged from 0 to 90%. Among these compounds, 2a (90%) and 2g (70%) showed maximum protection. Antimicrobial tests showed that the MIC value of 3j against Pseudomanas aeruginosa was equal to that of penicillin.