Organic Letters 2005-05-12

Highly enantioselective conjugate addition of nitromethane to chalcones using bifunctional cinchona organocatalysts.

Benedek Vakulya, Szilárd Varga, Antal Csámpai, Tibor Soós

Index: Org. Lett. 7 , 1967-1969, (2005)

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Abstract

Cinchona alkaloid-derived chiral bifunctional thiourea organocatalysts were synthesized and applied in the Michael addition between nitromethane and chalcones with high ee and chemical yields.

Structure	Name/CAS No.	Molecular Formula	Articles
	1-(3,5-BIS(TRIFLUOROMETHYL)PHENYL)-3-((1R)-(6-METHOXYQUINOLIN-4-YL)((2R,4S,5R)-5-VINYLQUINUCLIDIN-2-YL)METHYL)THIOUREA CAS:852913-25-8	C₂₉H₂₈F₆N₄OS
	nitromethane CAS:75-52-5	CH₃NO₂

Urea- and thiourea-substituted cinchona alkaloid derivatives...
2005-10-07
[Angew. Chem. Int. Ed. Engl. 44 , 6367-6370, (2005)]

Highly enantioselective conjugate addition of nitromethane to chalcones using bifunctional cinchona organocatalysts.

Abstract

Related Compounds