Chemical Communications 2013-04-25

Organometallic anticancer complexes of lapachol: metal centre-dependent formation of reactive oxygen species and correlation with cytotoxicity.

Wolfgang Kandioller, Evelyn Balsano, Samuel M Meier, Ute Jungwirth, Simone Göschl, Alexander Roller, Michael A Jakupec, Walter Berger, Bernhard K Keppler, Christian G Hartinger

Index: Chem. Commun. (Camb.) 49(32) , 3348-50, (2013)

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Abstract

Organometallic Ru(II), Os(II) and Rh(III) complexes of lapachol induce apoptosis in human tumour cell lines in the low μM range by a mode of action involving oxidative stress, especially in the case of the ruthenium compound.