Food and Chemical Toxicology 2012-06-01

Comparison of growth, serum biochemistries and n−6 fatty acid metabolism in rats fed diets supplemented with high-gamma-linolenic acid safflower oil or borage oil for 90 days

Patrick Tso, Jody Caldwell, Dana Lee, Gregory P. Boivin, Stephen J. DeMichele

Index: Food Chem. Toxicol. 50(6) , 1911-9, (2012)

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Abstract

Highlights ► Feeding diets containing HGSO or borage oil for 90days had similar biologic effects. ► Metabolism of primary n−6 fatty acids in plasma and organ phospholipids was similar. ► No adverse effects were observed with HGSO fed at 1980mg/kg bw/day and 2530mg/kg bw/day. ► HGSO is biologically equivalent to borage oil, providing a safe alternative source of GLA in the diet.