Molecules 2012-01-01

An ent-kaurane-type diterpene in Croton antisyphiliticus mart.

Sarazete Pereira, Silvia Taleb-Contini, Juliana Coppede, Paulo Pereira, Bianca Bertoni, Suzelei França, Ana Maria Pereira

Index: Molecules 17(8) , 8851-8, (2012)

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Abstract

Croton antisyphiliticus is a medicinal plant widely used in the treatment of microbial infections, especially those affecting the genital tract. Crude extract, fractions and pure compound isolated from roots of this species were investigated to validate their antimicrobial activity against Escherichia coli and Staphylococcus aureus. The compound ent-kaur-16-en-18-oic acid was isolated as a major component (0.7% of crude extract), and its MIC value determined against S. aureus (ATCC 6538) was 250 μg/mL. This is the first phytochemical work on the species monitored with antimicrobial assay.