Tetrahedron

Peptides—XIII: Effects of configuration on dielectric increments and cyclization of some simple peptides

PM Hardy, GW Kenner, RC Sheppard

Index: Hardy,P.M. et al. Tetrahedron, 1963 , vol. 19, p. 95 - 105

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Citation Number: 22

Abstract

Cyclization of the diastereoisomeric glycylleucylleucylglycylglycines, either through their p- nitrophenyl thiolesters or by means of dicyclohexyl carbodiimide, yields 39% of the DL and 12% of the ll cyclic pentapeptide. Correspondingly the dielectric increment of the open-chain dl pentapeptide is only 64% that of the ll, and similar differences have been found with several pairs of diastereoisomeric di-and-tri-peptides. A preliminary discussion of these ...