Molecular and Biochemical Parasitology 2012-08-01

Characterization of the M32 metallocarboxypeptidase ofTrypanosoma brucei: Differences and similarities with its orthologue inTrypanosoma cruzi

Alejandra P. Frasch, Adriana K. Carmona, Luiz Juliano, Juan J. Cazzulo, Gabriela T. Niemirowicz, Alejandra P. Frasch, Adriana K. Carmona, Luiz Juliano, Juan J. Cazzulo, Gabriela T. Niemirowicz

Index: Mol. Biochem. Parasitol. 184(2) , 63-70, (2012)

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Abstract

Graphical abstract Despite having 72% identity to TcMCP-1, T. brucei MCP-1 displays different substrate utilization. Comparative homology models led us to map several residues that could explain this difference.