Bioorganic & Medicinal Chemistry Letters 2011-07-15

Discovery of a novel class of 2-aminopyrimidines as CDK1 and CDK2 inhibitors.

Jinho Lee, Kyoung-Hee Kim, Shinwu Jeong

Index: Bioorg. Med. Chem. Lett. 21(14) , 4203-5, (2011)

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Abstract

A series of new 2-(2-aminopyrimidin-4-yl)phenol derivatives were synthesized as potential antitumor compounds. Substitution with pyrrolidine-3,4-diol at the 4-position of phenol provided potent inhibitory activity against CDK1 and CDK2. X-ray crystal structural studies were performed to account for the effect of the substituent on both the enzymatic and cell growth inhibitory activities.Copyright © 2011 Elsevier Ltd. All rights reserved.