Chemical Communications 2013-09-21

A ferrofluid-based homogeneous assay for highly sensitive and selective detection of single-nucleotide polymorphisms.

Wei Shen, Cai Le Lim, Zhiqiang Gao

Index: Chem. Commun. (Camb.) 49(73) , 8114-6, (2013)

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Abstract

A simple and low-cost colorimetric assay utilizing ferrofluidic nanoparticulate probes (FNPs) and a ligase for single-nucleotide polymorphism genotyping is described. Excellent sensitivity and selectivity were accomplished through the engagement of the FNPs and a ligase chain reaction.