ACS medicinal chemistry letters

Preparative microfluidic electrosynthesis of drug metabolites

R Stalder, GP Roth

Index: Stalder, Romain; Roth, Gregory P. ACS Medicinal Chemistry Letters, 2013 , vol. 4, # 11 p. 1119 - 1123

Full Text: HTML

Citation Number: 28

Abstract

In vivo, a drug molecule undergoes its first chemical transformation within the liver via CYP450-catalyzed oxidation. The chemical outcome of the first pass hepatic oxidation is key information to any drug development process. Electrochemistry can be used to simulate ...