Macromolecular Bioscience 2012-08-01

Antimicrobial hydantoin-containing polyesters.

Licheng Tan, Samarendra Maji, Claudia Mattheis, Mengyao Zheng, Yiwang Chen, E Caballero-Díaz, Pilar Rivera Gil, Wolfgang J Parak, Andreas Greiner, Seema Agarwal

Index: Macromol. Biosci. 12(8) , 1068-76, (2012)

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Abstract

A new N-hydantoin-containing biocompatible and enzymatically degradable polyester with antibacterial properties is presented. Different polyesters of dimethyl succinate, 1,4-butanediol, and 3-[N,N-di(β-hydroxyethyl)aminoethyl]-5,5-dimethylhydantoin in varying molar ratios are prepared via two-step melt polycondensation. The antibacterially active N-halamine form is obtained by subsequent chlorination of the polyesters with sodium hypochlorite. Chemical structures, thermal properties, and spherulitic morphologies of the copolymers are studied adopting FT-IR, NMR, TGA, DSC, WAXD, and POM. The polyesters exhibit antibacterial activity against Escherichia coli. The adopted synthetic approach can be transferred to other polyesters in a straightforward manner.Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.