Advanced Healthcare Materials 2012-07-01

Stealth rare earth oxide nanodiscs for magnetic resonance imaging.

Mark J Bailey, Rob van der Weegen, Piper J Klemm, Suzanne L Baker, Brett A Helms

Index: Adv. Healthc. Mater. 1(4) , 437-42, (2012)

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Abstract

Configuring RE(2) O(3) nanocrystals with pseudo-2D morphologies confers substantive gains in relaxivities over equivalent spherical counterparts. The most promising arises from Gd(2) O(3) whose ionic transverse and longitudinal relaxivities were as high as r(1) = 12.7 mM(-1) s(-1) and r(2) = 17.2 mM(-1) s(-1) (dispersed in H(2) O, T = 37 °C & B(0) = 1.41 T), pointing to new opportunities to achieve high contrast MRI while concomitantly affording longer half-life potential in vivo.Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.