Organic Letters 2003-01-23

Asymmetric hydrogenation of itaconic acid and enol acetate derivatives with the Rh-TangPhos catalyst.

Wenjun Tang, Duan Liu, Xumu Zhang

Index: Org. Lett. 5 , 205, (2003)

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Abstract

[reaction: see text] The Rh-TangPhos catalyst has been used for asymmetric hydrogenation of itaconic acid and enol acetate derivatives. A variety of chiral 2-substituted succinic acids and chiral acetates have been obtained in excellent ee values (up to 99% ee).