Chemical Biology & Drug Design 2010-03-01

Design of a versatile multicomponent reaction leading to 2-amino-5-ketoaryl pyrroles.

Kan Wang, Alexander Dömling

Index: Chem. Biol. Drug Des. 75(3) , 277-83, (2010)

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Abstract

The design of an unprecedented multicomponent reaction to and synthesis of 2-amino-5-ketoaryl pyrroles are described. The compounds (14 examples) can be synthesized by reacting aminoacetophenone sulfonamides, (hetero)aromatic aldehydes, and malonodinitrile or cyanoacetic acid derivatives in one-pot manner. Pharmacophore features and potential applications of this new scaffold are discussed.