Journal of the American Chemical Society 2005-04-06

Asymmetric nickel-catalyzed Negishi cross-couplings of secondary alpha-bromo amides with organozinc reagents.

Christian Fischer, Gregory C Fu

Index: J. Am. Chem. Soc. 127 , 4594, (2005)

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Abstract

A Ni/Pybox catalyst achieves the asymmetric cross-coupling of secondary alpha-bromo amides with organozinc reagents. The process tolerates a variety of functional groups and affords the desired product in good yield and in high enantiomeric excess.