Bioorganic & Medicinal Chemistry 2002-11-01

Synthesis and biological evaluation of A-ring biaryl-carbamate analogues of rhazinilam.

Olivier Baudoin, Fabien Claveau, Sylviane Thoret, Audrey Herrbach, Daniel Guénard, Françoise Guéritte

Index: Bioorg. Med. Chem. 10(11) , 3395-400, (2002)

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Abstract

An improvement of the synthesis of biphenyl-carbamate 2a, the most active analogue of rhazinilam 1 so far, was performed using the Pd-catalyzed borylation/Suzuki coupling (BSC) method developed in our laboratories. The preparation of A-ring analogues of 2a bearing electron-withdrawing or donating groups is reported according to this new synthetic scheme. The antitubulin properties as well as the cytotoxicity of these compounds toward human cancer cell lines were evaluated in comparison with rhazinilam and 2a.