A concise, convergent racemic synthesis of BMS-708163 is reported. Two fragments consisting of N-4-chlorophenylsulfonyl-3, 3, 3-trifluorpropylglycine and a 1, 2, 4-oxadiazole derivative of 2-fluorobenzyl alcohol were prepared in separate pots and then coupled together via a Mitsunobu reaction. Since a convenient chiral synthesis of optically pure (d)-3, 3, 3-trifluoropropyl glycine methyl ester was developed using Schöllkopf reagent ...
