Interaction between the low molecular mass components of blood serum and the VO (iv)–DHP system (DHP= 1, 2-dimethyl-3-hydroxy-4 (1 H)-pyridinone)

P Buglyó, T Kiss, E Kiss, D Sanna, E Garribba…

Index: Buglyo, Peter; Kiss, Tamas; Kiss, Erzsebet; Sanna, Daniele; Garribba, Eugenio; Micera, Giovanni Journal of the Chemical Society, Dalton Transactions, 2002 , # 11 p. 2275 - 2282

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Citation Number: 18

Abstract

In order to estimate the impact of the low molecular mass (lmm) VO (IV) binders of blood serum on the potentially insulin-enhancing drug [VO (DHP) 2][DHP= 1, 2-dimethyl-3-hydroxy- 4 (1H)-pyridinone], the speciation in the binary system VO (IV)–DHP and in the ternary systems VO–DHP–ligand B (B= oxalate, lactate, citrate or phosphate) was studied by pH- potentiometry at 25.0° C and at an ionic strength I= 0.2 mol dm− 3 (KCl). The binding ...