Aporphines. 31. Synthesis and antitumor activity of aporphine nitrogen mustards

JL Neumeyer, FE Granchelli, CN Filer…

Index: Neumeyer, John L.; Granchelli, Felix E.; Filer, Crist N.; Soloway, Albert H.; Law, Say-Jong Journal of Medicinal Chemistry, 1980 , vol. 23, # 9 p. 1008 - 1013

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Citation Number: 2

Abstract

A series of aporphine nitrogen mustards and their congeners (lb-g) has been prepared. N- [[Bis (2-chloroethyl)-amino] acetyl]-2, 11-dihyroxy-lO-methoxynoraporphine (lb) and its mono- and diacetyl ester derivatives (lc-d) were prepared from N-(chloroacetyl)-2, 1l-diacetoxy-lO- methoxynoraporphine (2). Reaction of 2 with diethanolamine under various conditions and different solvents resulted in the corresponding N-[[bis (2-hydroxyethyl) amino] acetyl] ...