Bioorganic & Medicinal Chemistry Letters 2007-04-01

Anti-formyl peptide antibodies.

Fujie Tanaka, Teresa Jones, Diane Kubitz, Richard A Lerner

Index: Bioorg. Med. Chem. Lett. 17 , 1943-1945, (2007)

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Abstract

Antibodies that selectively bind to N-formylmethionyl leucyl phenylalanine (fMLF, also known as fMLP) have been generated. These antibodies bound to fMLF with higher affinity than to non-formylated peptide MLF: the differences in the binding energies between fMLF and MLF were 1.4->2.1 kcal/mol.