Advances in Biological Regulation 2013-01-01

Molecular mechanisms of fMLP-induced superoxide generation and degranulation in mouse neutrophils.

Yasunori Kanaho, Takanobu Sato, Tsunaki Hongu, Yuji Funakoshi

Index: Adv. Biol. Regul. 53(1) , 128-34, (2013)

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Abstract

In this manuscript, involvement of PLD in fMLP-induced superoxide generation and degranulation were re-investigated using PLD(-/-) neutrophils, and the molecular mechanisms of these neutrophil functions were examined. Neither PLD1 nor PLD2 is involved in these fMLP-induced neutrophil functions. The results obtained in this study provide evidence that cPKC plays an important role in fMLP-induced superoxide generation. On the other hand, Ca(2+)-dependent signaling pathway and cPKC seem to be involved in degranulation.Copyright © 2012 Elsevier Ltd. All rights reserved.