Brain Research 1986-06-11

Inhibition by neosurugatoxin of nicotine-induced antinociception.

S Yamada, Y Kagawa, N Takayanagi, E Hayashi, K Tsuji, T Kosuge

Index: Brain Res. 375(2) , 360-2, (1986)

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Abstract

We have found a selective inhibition of nicotine-induced antinociception in mice by neosurugatoxin (NSTX, 0.4-3.8 nmol/kg), a neurotoxin with a high affinity for ganglionic nicotinic receptors (ED50 = 0.65 nmol/kg). The toxin also reduced specific [3H]nicotine binding in mouse brain membranes (IC50 = 95 nM). The anti-nicotinic activity of NSTX was markedly greater than that of mecamylamine and pempidine. These data indicate that NSTX may block functional nicotinic cholinoceptors possibly in the central nervous system.